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Our laboratory

GeneTech’s central laboratory located in Hyderabad across the picturesque KBR Park at Banjara Hills is the largest facility for any independent medical genetics lab in India. Our facility houses labs for all technologies applied in medical genetics and genomics to provide accurate and timely diagnosis

Cytogenetics lab

Cytogenetics laboratory performs chromosomal analysis (Karyotyping) of a variety of tissues including peripheral blood, bone marrow, amniotic fluid, chorionic villus sample, cord blood, products of conception, placenta, foetal blood, foetal skin and tumour samples.

We maintain sterile conditions which are crucial for tissue culture, especially for prenatal samples. We use sophisticated equipment like CO2 incubators, advanced microscopes, high-resolution image analysis, and automated karyotyping systems.

Next Generation Sequencing Lab

Next Generation Sequencing (NGS) involves sequencing millions of DNA fragments in parallel to obtain vast amounts of data affordably.
Utilising multiple target enrichment methods and our in-house expertise, GeneTech has developed NGS panels in various disease areas to facilitate quick diagnosis in areas such as reproductive genetics, growth and development genetics, and various inherited conditions.

FISH Lab

Fluorescent in situ hybridisation technology uses fluorescent primer probes and detects deletions and duplications of DNA sequences on the chromosomes. This technique is used to quickly identify any extra or deleted chromosome (Aneuploidy) or to detect deletions and duplications of parts of chromosomes.

Our FISH lab uses the best hybridisation technology available in the world today with probe design and automated fluorescent microscopy along with image analysis for accurate aneuploidy and microdeletion detection.

RT qPCR Lab

Real-Time PCR Lab at GeneTech offers a large number of testing options from TaqMan-based Drug Metabolism Enzyme (DME) genotyping to SYBR Green Dye-based gene expression studies, copy number analysis, microRNA profiling as well as Long noncoding RNA (lncRNA) expression analysis

Molecular Lab

Mutation analysis or DNA testing in our molecular laboratory detects genetic mutations at a single gene level which include SNPs, mutations, deletions, duplications, nucleotide repeats, inversions and insertions using cutting-edge technology. Lab uses advanced molecular technologies such as PCR (ARMS PCR, Multiplex PCR, RFLP) and the Sanger sequencing method for single gene mutations. Advanced molecular technologies include Next Generation Sequencing (NGS) or high throughput sequencing to test multi-gene panels and Microarray testing (750K) for unknown syndrome identification by examining multiple genomic areas.

Our molecular lab is equipped with sequencers, thermal cyclers, real-time PCR, spectrophotometers, automated gel documentation systems, and sterile rooms with large storage facilities.

Our molecular lab results are analysed by expert molecular biologists and medical genetics and interpreted with great care and attention based on case details. The report elaborated on identified mutation, phenotype and genotype correlation, recurrence risk, prenatal options, predisposition (if applicable) and detailed recommendations.

Biochemical lab

The biochemical genetics lab performs qualitative and quantitative analyses of various markers proteins or enzymes.  The lab uses advanced technologies such as Chemiluminescence (CLIA) methods, Enzyme-linked immunosorbent assay (ELISA), time-resolved Fluorometry, Chromatography and Tandem Mass spectrometry.

Our biochemical lab offers prenatal screening for Down syndrome, Patau syndrome, Edward syndrome, Open neural tube defects (ONTD) and Preeclampsia by analysing foetal markers in maternal blood (AFP, beta hCG, UE3, Inhibin). Our IndiScreen Software, developed purely based on Indian population data, calculates foetal risk with a low false positive rate and high detection rate. 

Our Newborn screening programs offer routine screening for common metabolic disorders based on the heel prick collection method. Advanced screening is based on Spectrometry and Enzyme analysis.

Sequencing Lab

The Sequencing Lab at GeneTech offers rapid confirmation of variants reported in Next-Gen Sequencing and also offers prenatal diagnosis options for extremely rare mutations. In addition, the lab offers Multiple Ligation-dependent Probe Amplification (MLPA) testing, fragment analysis and multiplex genotyping services on its capillary sequencing platform.